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Gunmen in Iran opened fire inside a Shiite holy shine Wednesday evening, killing at least 15 people and wounding more than 40 others, according to official sources.
The attack occurred at the Shah Cheragh shrine in the city of Shiraz.
State media have called it a "terrorist" attack and said two of suspects have been arrested.
Islamic State is claiming responsibility for the attack.
NEW: #ISIS claiming responsibility for an attack on a shrine in #Iran that left 15 people dead and +40 others wounded via its Amaq news agency, other forumsAmaq claims the attacker first opened fire on Iranian police before gathering worshippers, via @JihadoScope pic.twitter.com/YyGmcSxrR2
The attack took place on the same day hundreds of protesters marched to the gravesite of Mahsa Amini in northwestern Iran to mark 40 days since her death while in custody of the nation's morality police.
Amini, a Kurdish woman, was detained by the morality police in the capital, Tehran, September 13 for allegedly wearing her head scarf - or hijab - "improperly." The 22-year-old died while custody three days later, with police reporting she had a heart attack. Her family says she had no history of heart trouble.
Rights groups say more than 200 people have died during the protests over her death and hundreds, if not thousands, have been arrested. Analysts say the protests have become one of the most serious challenges to the Islamic Republic in its history.
VOA National Security Correspondent Jeff Seldin contributed to this report.